Enjoying and learning every day in protein research in Zaragoza
We gather diverse academic trainings, which make us quite a versatile group. While our expertises change from time to time, we often combine web lab experiments with biocomputation to solve specific problems using a variety of techniques. We work both in individual projects and in collaborative projects involving several members of the group and/or external collaborators worldwide.
Zaragoza provides a pleasant atmosphere to visitors and residents alike and has many things to discover and very friendly people to enjoy them with. Most of the time, our group enjoys an international composition which enriches us greatly.
Know the Team
I am a post-doc researcher expert in Structural Bioinformatics and Computational Drug Desing. My main "bussines" in research are all-atom molecular dynamics simulations, molecular docking, QSAR, proteomic bioinformatics, protein thermodynamics, statistics and some protein biophysics.
I am a full time PhD student, a chemist in project to be something else in the biochemical world.
Organic synthesis is my biggest daily challenge.
Passionated about basketball or any sport that is proposed to me.
Extremely restless girl with many hobbies. My leisure time is always busy, and I love it!
I am an Early Stage Researcher. Mostly I am focused on the development of novel personalized drugs for infectious and conformational diseases. Currently, I am working on a multi-omics-based pipeline for rapid and precise antimicrobial drug development.
I am a PhD student in the field of Structural Bioinformatics, specializing in Molecular Dynamics analysis and stability prediction upon mutation using relaxation Molecular Dynamics, databases, metaprediction, sequence homology and structural analysis. Activist for diversity in STEM. Out of the lab, also an amateur actress, musician and singer.
I feel a bit like a Swiss Army knife. I have enjoyed to work on projects that span many aspects of computer science. I am comfortable with web and application development, without forgetting the graphic design part. I also like new ways of interaction with computers like VR/AR. And when I am not absorbed with a computer I like to disconnect in nature.
Apoflavodoxin folding and molecular interactions in proteins: energetic and mutational analysis.
Ana Isabel Gracia
Modulation of the redox potential of electron transport proteins by amino acids of the active site.
Study of the initial stages of protein folding with complementary protein fragments.
Structure of the thermal intermediate and the unfolding transition state of apoflavodoxin. Energetics of charged and neutral hydrogen bridges.
Towards the generation of ligand-bearing proteins: molecular modeling of protein-ligand complexes and automatic screening of ligand libraries.
Energetic and structural analysis of a model protein with a three-state equilibrium: flavodoxin from Anabaena PCC 7119.
Stability and stabilization of proteins with the Anabaena PCC 7119 apoflavodoxin model.
Conformational Stability of an Anti Hepatitis C Antibody and a Derived ScFv Mini Antibody.
Helicobacter pylori flavodoxin: conformational landscape and identification of specific inhibitors.
Structural and thermodynamic analysis of the conformations that populate the thermal denaturation of apoflavodoxin from Anabaena PCC 7119.
A bioinformatics study of the conformational flexibility and misfolding of proteins.
Computational tools for the study of protein stability and the interaction between proteins and small molecules.
Helicobacter pylori: Biomolecular events associated with the appearance of resistance and the anion / water exchange mechanism on the surface of Fld. Optimization design of new compounds with pharmacological activities.
Rational stabilization of apoflavodoxin from Anabaena PCC 7119 and study of the relevance of its thermal intermediate.
Universidad de Concepción (Chile)
Biochemical and structural characterization of flavodoxin from Streptococcus pneumoniae strain TIGR4.
New therapeutic and analytical tools based on organic molecules with the ability to interact with proteins implicated in Alzheimer's disease, Parkinson's disease, phenylketonuria and the infection caused by Helicobacter pylori.
Aarhus University (Denmark)
Combating resistance associated with Helicobacter pylori: synthesis and in vivo evaluation of new antimicrobials against specific bacterial targets.